Disease Overview

Information about Non-Cystic Fibrosis Bronchiectasis (NCFBE)

What is NCFBE?

NCFBE is a disease of the lungs, where the airways (called the bronchi and bronchioles) become enlarged (widen) and this may make breathing more difficult.

What causes NCFBE?

It can be caused by an infection or another condition – sometimes the cause is not known. In patients with NCFBE, the body’s defence system (immune system) overreacts to a foreign substance in the airways (e.g. an infection with a bacteria or virus), and causes permanent damage to the tissue and muscles surrounding the airways, causing them to widen. This makes it more likely that the patient may suffer more infections. Each infection leads to further reaction by the immune system and could cause damage to the lungs.

What are the symptoms of NCFBE?

Symptoms typically include a long-lasting dry or wet cough. Other symptoms can include shortness of breath, wheezing, coughing up blood and chest pain. Patients may have recurrent chest infections.

Are there any benefits or risks to participating in the WILLOW Study?

The WILLOW Study treatments and procedures carry a certain amount of risk. The study centre doctor will talk to you about possible side effects you might experience during the study. As we do not know all the side effects of this treatment, there may be side effects that we cannot predict. It is important that, at each visit, you report any and all symptoms or health problems to the study centre doctor, whether or not you think these problems are related to the study treatment.